What is Adbry?
Not an actual patient.
Individual results may vary.
About atopic dermatitis (eczema)
is a type of . In fact, it’s the most common type, affecting over 16 million adults in the United States.
is a skin disease that’s caused by an overactive . When the is triggered, it causes , and your skin can become itchy, red, and dry.
With , the overactive causes . So even when symptoms aren’t present on your skin, can still be happening under your skin.
Common symptoms of moderate-to-severe include:
- Dry or scaly skin
- Darkening of the skin
- Thickening of the skin
- Reddening of the skin
- Small raised bumps
can be exhausting and often unpredictable—appearing on different parts of the body. For adults, most commonly appears on the neck, hands, arms, back of the knees, and inside the elbows.
While the exact cause of is unknown, we do know that people with have an overactive and a weakened that causes damage to the skin. That overactive produces a number of proteins in the body—one of which is (interleukin-13). is a protein that sends signals that lead to in the skin.
Studies have shown that people with have more in their skin than people without . It’s also been shown that the more people have, the more severe their is.
When too much is present in the skin, it leads to continued and unbearable itch. When you scratch your skin, the weakens and becomes more damaged, allowing substances such as bacteria, allergens, and viruses to enter.
When the immune system detects these substances, the body produces more in the skin, starting the vicious cycle again.
Adbry® (tralokinumab-ldrm) is an injection for adults with moderate-to-severe , a type of .
It’s a prescription medicine for those who:
- Don’t get relief from prescription topical therapies
- Can’t use prescription topical therapies
You can use Adbry with and without topical steroids.
Children should not use Adbry.
Adbry is not a cream, an ointment, or a pill. And it’s not a . It’s a treatment that helps calm the that leads to the symptoms of .
Adbry works inside the body to help get clearer skin and control the unbearable itch.
Adbry is the first and only injection that specifically targets , one of the proteins in the immune system that contributes to skin in .
Adbry was studied in 3 separate clinical trials of almost 2,000 adults aged 18 and older with moderate-to-severe (). People in the trials injected 2 prefilled syringes every other week.
TRIAL 1: 601 people used Adbry; 197 used
TRIAL 2: 577 people used Adbry; 193 used
TRIAL 3: 243 people used Adbry + ; 123 used +
The safety of Adbry was studied in 5 clinical trials.
Before using Adbry, tell your healthcare provider about all your medical conditions, including if you:
- have eye problems.
- have a parasitic (helminth) infection.
- are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with Adbry.
- are pregnant or plan to become pregnant. It is not known whether Adbry will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known whether Adbry passes into your breast milk and if it can harm your baby.
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
For information on how to prepare and inject Adbry, and how to properly store and throw away used Adbry prefilled syringes and syringe covers, download the Instructions for Use
Adbry can cause serious side effects, including:
- Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using Adbry and tell your healthcare professional or get emergency help right away if you get any of the following symptoms:
- breathing problems
- skin rash
- swelling of the face, mouth, and tongue
- fainting, dizziness, feeling lightheaded (low blood pressure)
- Eye problems. Tell your healthcare provider if you have any worsening eye problems, including eye pain or changes in vision.
The most common side effects of Adbry include:
- Eye and eyelid , including redness, swelling, and itching
- Injection site reactions
- High count of a certain white blood cell (eosinophilia)
These are not all of the possible side effects of Adbry. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
On the first day of treatment with Adbry, your healthcare professional will give you your initial (or loading) dose of 4 injections. This dose helps start to build up the medicine in your body.
Then, your healthcare professional will show you or your caregiver how to inject Adbry, just under your skin.
After you learn to inject Adbry and receive your loading dose, you will inject 2 prefilled syringes at home every other week.
After 4 months, if you have clear or almost clear skin and weigh under 220 lbs, your healthcare professional may determine if your dose may be changed to 2 prefilled syringes every 4 weeks. Use Adbry exactly as told by your healthcare professional.
Adbry is an injection given under the skin (also known as a ).
Watch Emma’s injection routine with Adbry® (tralokinumab-ldrm). She breaks down the steps and shows you how to properly inject your full maintenance dose of Adbry every other week.
Your healthcare professional will show you or your caregiver how to inject Adbry under your skin.
After you learn to inject Adbry and receive your loading dose of 4 prefilled syringes, you will inject 2 prefilled syringes at home every other week for your maintenance dose.
Always read the Instructions for Use that comes with your Adbry carton before self-injecting.
You can choose to inject Adbry in your stomach (abdomen) or thigh. If you prefer to have help from a caregiver, they can inject in your upper arm after a healthcare professional shows them how to do it.
You should inject both syringes in the same area of your body while keeping them at least 1 inch apart.
Remember that each time you inject a new set of injections (every other week), you should rotate and choose a different injection area. Do not use the same body area two times in a row.
If you miss a dose, inject the missed dose as soon as possible, then continue with your next dose at your regular scheduled time. If you have any questions, call your healthcare professional.
If you accidentally inject more Adbry than you’re prescribed, call Poison Control at 1-800-222-1222.
Adbry should be stored in the refrigerator between 36°F and 46°F (or 2°C and 8°C).
Don’t freeze the syringes or use syringes that have been previously frozen.
Like all medicines, Adbry should be kept out of the reach of children.
Remember to remove both syringes from the refrigerator 30 minutes before you are ready to self-inject. Don’t try to speed up this process by warming up the syringes in the microwave, running under hot water, or placing in direct sunlight. Simply let the syringes warm up to room temperature by lying the carton flat on a table or counter out of direct light.
All used syringes and syringe covers should be thrown away in a puncture-resistant .
When your container is almost full, follow your local guidelines for disposal. Depending on where you live, there may be state or local laws to follow.
For more information about safe sharps disposal, and for specific information about disposal in the state where you live, visit the FDA’s website.
Adbry is a injection that requires special shipping and handling by a . are similar to local pharmacies in a number of ways. The major difference between the two is that a manages medicines that require special handling (e.g., require refrigeration).
Once you’ve been prescribed Adbry your will process your prescription, confirm your shipping address over the phone, and then deliver the medicine to your home by mail.
Ask your healthcare professional about which are located near you.
The Adbry® Advocate™ Program is here to help you through the process. Call 844-MY-ADBRY (844-692-3279) for help coordinating your Adbry shipment.
For information on how to prepare and inject Adbry, and how to properly store and throw away used Adbry prefilled syringes, download the Instructions for Use.
You can also watch this step-by-step Self-Injection Video.
Have questions about Adbry or the self-injection process? Those enrolled in the Adbry® Advocate™ Program can receive virtual injection training upon request. Call 844-MY-ADBRY (844-692-3279) for more information.