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Uncontrolled eczema can
come and go without warning

Atopic dermatitis is the most common type of eczema, affecting over 16 million
adults in the United States.

Explore symptoms

Chronic inflammation
underneath the surface

Normal skin and eczema skin comparison example.

Chronic inflammation
underneath the surface

Eczema is a chronic skin disease that’s caused by an overactive immune response. When the immune response is triggered, it causes inflammation, and your skin can become itchy, red, and dry.

With eczema, the overactive immune response causes inflammation. So even when symptoms aren’t present on your skin, inflammation can still be happening under your skin.

” ”I’ve been suffering from eczema
for my whole life.”

Beth
A real Adbry patient.
Individual results may vary.

Beth, a real Adbry® patient, showcasing her experience with Adbry®, with individual results varying

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treatment goals and questions
at your next doctor visit.

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How IL-13 triggers eczema inflammation

While the exact cause of eczema is unknown, we do know that people with eczema have an overactive immune response and a weakened skin barrier that causes damage to the skin. That overactive immune response produces a number of proteins in the body—one of which is IL-13 (interleukin-13). IL-13 is a protein that sends signals that lead to inflammation in the skin.

Studies have shown that people with eczema have more IL-13 in their skin than people without eczema. It’s also been shown that the more IL-13 people have, the more severe their eczema.

The itch-scratch cycle

When too much IL-13 is present in the skin, it leads to continued inflammation and unbearable itch. When you scratch your skin, the skin barrier weakens and becomes more damaged, allowing substances such as bacteria, allergens, and viruses to enter.

When the immune system detects these substances, the body produces more IL-13 in the skin, starting the vicious cycle again.

The itch-scratch cycle

The cycle of inflammation, scratch, and itch related to eczema.

For illustrative purposes.
Actor portrayal.

What can moderate-to-severe eczema look like?*

Dry or scaly skin due to moderate-to-severe eczema.

Dry or scaly skin

Darkening of the skin due to moderate-to-severe eczema.

Darkening of the skin

Itching due to moderate-to-severe eczema.

Itching

Thickening of skin due to moderate-to-severe eczema.

Thickening of the skin

Reddening of the skin due to moderate-to-severe eczema.

Reddening of the skin

Small raised bumps on skin due to moderate-to-severe eczema.

Small raised bumps

Moderate-to-severe eczema can appear at different times on different body parts.
Eczema most commonly appears on the neck, hands, arms, back of the knees, and inside
of the elbows. The photos above do not show all possible symptoms.

*Images show common symptoms of moderate-to-severe atopic dermatitis (eczema) and may not represent all
possible symptoms, which can appear at different times.

Patient video of Beth, a real Adbry® patient.

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real Adbry patients

Individual results may vary.

How Adbry® can help

Clearer skin and
itch control is possible.

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INDICATION

What is ADBRY® (tralokinumab-ldrm)?

  • ADBRY® (tralokinumab-ldrm) injection is a prescription medicine used to treat people 12 years of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. ADBRY can be used with or without topical corticosteroids.
  • It is not known if ADBRY is safe and effective in children under 12 years of age.

Do not use ADBRY if you are allergic to tralokinumab or to any of its ingredients.

Please see full Prescribing Information, including Patient Information and Instructions for Use.

IMPORTANT SAFETY INFORMATION AND INDICATION

IMPORTANT SAFETY INFORMATION

What should I discuss with my healthcare provider before starting ADBRY?

Tell your healthcare provider about all your medical conditions, including if you:

  • have eye problems.
  • have a parasitic (helminth) infection.
  • are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with ADBRY.
  • are pregnant or plan to become pregnant. It is not known whether ADBRY will harm your unborn baby. There is a pregnancy exposure registry for women who use ADBRY during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. You or your healthcare provider can get information and enroll you in this registry by calling 1-877-311-8972 or visiting https://mothertobaby.org/ongoing-study/adbry-tralokinumab/.
  • are breastfeeding or plan to breastfeed. It is not known whether ADBRY passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use ADBRY?

  • See the detailed “Instructions for Use” that comes with ADBRY for information on how to prepare and inject ADBRY and how to properly store and throw away (dispose of) used ADBRY prefilled syringes and autoinjectors.
  • Use ADBRY exactly as prescribed by your healthcare provider.
  • Your healthcare provider will tell you how much ADBRY to inject and when to inject it.
  • ADBRY comes as a single-dose prefilled syringe with needle guard or as an autoinjector.
  • ADBRY is given as an injection under the skin (subcutaneous injection).
  • If your healthcare provider decides that you or a caregiver can give the injections of ADBRY, you or your caregiver should receive training on the right way to prepare and inject ADBRY. Do not try to inject ADBRY until you have been shown the right way by your healthcare provider. In children 12 years of age and older, it is recommended that ADBRY be given by or under supervision of an adult.
  • If you miss a dose, inject the missed dose as soon as possible, then continue with your next dose at your regular scheduled time.
  • If you inject too much ADBRY than prescribed, call your healthcare provider or call Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.
  • Your healthcare provider may prescribe other medicines to use with ADBRY. Use the other prescribed medicines exactly as your healthcare provider tells you to.

What are the possible side effects of ADBRY?

ADBRY can cause serious side effects, including:

  • Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using ADBRY and tell your healthcare provider or get emergency help right away if you get any of the following symptoms:
    • breathing problems
    • itching
    • skin rash
    • swelling of the face, mouth, and tongue
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • hives
  • Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.

The most common side effects of ADBRY include:

  • Upper respiratory tract infections
  • Eye and eyelid inflammation, including redness, swelling, and itching
  • Injection site reactions
  • High count of a certain white blood cell (eosinophilia)

These are not all the possible side effects of ADBRY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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